Waltz+Round+the+Cycle

=**Waltz Round the Cycle**=

Once a jolly pyruvate enters the matrix Of a mitochondrion, so they say, A decarboxylating, complex dehydrogenase Converts it to acetyl co-enzyme A.

Waltz round the cycle Waltz round the cycle Waltz round the TCA cycle today. A decarboxylating, complex dehydrogenase Turns pyruvate to acetyl CoA.

Oxaloacetate looking for a partner Thinks "active acetate" looks OK; Citrate sythase arranging the merger Makes a new citrate, and kicks out CoA.

Waltz round the cycle Waltz round the cycle Waltz round the TCA cycle today Citrate sythase arranging the merger Makes a new citrate, and kicks out CoA.

Along comes aconitase, a hydro-dehydratase, Gives isocitrate reversibly. Then its dehydrogenase gives NADH, Carbon dioxide and α-KG.

Waltz round the cycle Waltz round the cycle Waltz round the TCA cycle with me Then its dehydrogenase gives NADH, Carbon dioxide and α-KG.

Off with the CO2. Another oxidation Just like the PDC previously. Succinyl CoA with a synthatase Yields succinate and GTP.

Waltz round the cycle Waltz round the cycle Waltz round the TCA cycle with me Succinyl CoA with a synthatase Yields succinate and GTP.

Succinate's oxidized by its dehydrogenase Reducing FAD, giving fumarate; Fumarase makes malate; another dehydrogenase Regenerates Oxaloacetate.

Waltz round the cycle Waltz round the cycle Waltz round the TCA cycle, mate Fumarase makes malate; another dehydrogenase Regenerates Oxaloacetate.

**Abbreviations:**

 * TCA - tricarboxylic acid
 * α-KG - α-ketogularate
 * PDC - Pyruvate dehydrogenase complex